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蟾毒靈

分析標準品,HPLC≥98%

Bufalin

CAS號：465-21-4

分子式： C24H34O4

分子量：386.53

MDL：MFCD00056525

產品介紹

熔點：242-243℃

沸點：556.6 ℃ at 760 mmHg

比旋光度：D -20°

外觀：針狀晶體

溶解性：DMSO  :  100  mg/mL  (258.72  mM;  Need  ultrasonic)

儲存條件：2-8℃

注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(33篇)

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32. [IF=5.4] Ruifeng Zeng et al."Tumor-targeted nanosystem with hypoxia inducible factor 1α inhibition for synergistic chemo-photodynamic therapy against hypoxic tumor."COLLOIDS AND SURFACES B-BIOINTERFACES.2024 Dec;:114456

31. [IF=8.2] Tao Li et al."Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway."International Journal of Biological Sciences.2025 Jan;21(1):285

30. [IF=4.8] Hongxuan Yang et al."Huachansu suppresses colorectal cancer via inhibiting PI3K/AKT and glycolysis signaling pathways: Systems biology and network pharmacology."JOURNAL OF ETHNOPHARMACOLOGY.2025 Feb;:119479

29. [IF=8] Qing Zhang et al."MMP-2 Responsive Peptide Hydrogel-Based Nanoplatform for Multimodal Tumor Therapy."International Journal of Nanomedicine.

28. [IF=7.9] Yi-Qing Deng et al."Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities."PHYTOMEDICINE.2023 Oct;:155169

27. [IF=4.8] Zijun Qian et al."Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway."CELLULAR SIGNALLING.2023 Sep;109:110746

26. [IF=1.902] Ke-ke Cui et al."Quantitative analysis of multicomponents by a single marker and quality evaluation of Venenum Bufonis from different geographical origins."Biomed Chromatogr. 2019 Sep;33(9):e4555

25. [IF=3.565] Liqiang Qian et al."Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer."J Cancer. 2020; 11(11): 3114–3123

24. [IF=4.379] Cao  Yueting et al."The impact of multiple climatic and geographic factors on the chemical defences of Asian toads (Bufo gargarizans Cantor)."Sci Rep-Uk. 2019 Nov;9(1):1-11

23. [IF=4.411] Yueting Cao et al."Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins."Molecules. 2019 Jan;24(19):3595

22. [IF=9.381] Haiyan Hu et al."Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy."Carbohyd Polym. 2020 Aug;241:116335

21. [IF=2.193] Zhang Mei-Tuo et al."Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC."J Anal Methods Chem. 2018;2018:7569283

20. [IF=2.311] Jinlin Xie et al."Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway."Oncol Lett. 2018 Sep;16(3):3867-3873

19. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells."Fund Clin Pharmacol. 2017 Dec;31(6):695-700

18. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L-type Ca2+ channels and contractility in rat ventricular myocytes."Fund Clin Pharmacol. 2017 Jun;31(3):340-346

17. [IF=3.743] Yu-Long Lan et al."Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase α1 subunit."Biomed Pharmacother. 2018 Jul;103:204

16. [IF=4.101] Yao  Liu et al."Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice."Int J Mol Med. 2017 Aug;40(2):357-366

15. [IF=6.284] Lan  Yu-Long et al."The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway."Cell Biol Toxicol. 2019 Dec;35(6):521-539

14.  Haiyan Hu, Qi Qi, Ziyi Dong, Xianglong Yu, Yujia Mo, Juyuan Luo, Yan Wang, Shouying Du, Yang Lu,

Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy,

Carbohydrate Polymers,

Volume 241,

2020,

13.  Xie, Jinlin, et al. "Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway." Oncology letters 16.3 (2018): 3867-3873.https:##doi.org/10.3892/ol.2018.9111

12.  Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L‐type Ca2+ channels and contractility in rat ventricular myocytes." Fundamental & clinical pharmacology 31.3 (2017): 340-346.https:##doi.org/10.1111/fc

11.  Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK 293 cells." Fundamental & clinical pharmacology 31.6 (2017): 695-700.https:##doi.org/10.1111/fcp.12306

10.  Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https:##doi.org/10.3892/ijmm.2017.3039

9.  Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https:##doi.org/10.3892/ijmm.2017.3039

8.  曹月婷  崔可可  吳紀恒 等. 中華大蟾蜍毒液中蟾毒配基類成分的相關性研究[J]. 中國中藥雜志  2019(9).

7.  房蘊歌, 王鵬飛, 朱厚達,等. 蟾酥藥材和飲片(蟾酥粉)的質量標準研究[J]. 中國中藥雜志, 2020(8).

6.  張妹砣  李玉桑  葉曉雪. 六神丸血漿藥物化學的研究[J]. 綠色科技  2017  000(012):237-240.

5.  田志輝, 張培, 曹彥坤,等. 蟾蜍靈抑制食管癌細胞增殖、遷移和趨化運動的機制研究[J]. 中國現代醫學雜志, 2015(20):50-54.

4.  丁妍,王小玲,鄧會巖,蘇麗宏,張培,劉月平.蟾蜍靈抑制Raf/MEK/細胞外信號調節激酶信號通路活化影響人食管鱗癌細胞增殖及遷移機制研究[J].中國全科醫學,2015,18(21):2535-2541.

3.  陳硯凝, 劉堯, 王小玲,等. 蟾蜍令靈對裸鼠食管鱗癌原位移植瘤中 P70S6K 表達的影響[J]. 中國全科醫學, 2015(15期):1763-1767.

2.  張玲玲  韓金薇  王曉琳  et al. Bufalin抑制食管癌TE13細胞遷移機制探討[J]. 中華腫瘤防治雜志  2016  23(13):837-843.

1.  丁妍  王小玲  柳慧 等. Bufalin促進人食管癌細胞ECA109凋亡的研究[J]. 食管外科電子雜志  2014(02):49-54.

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